Entwicklung eines in vitro Systems zur Untersuchung von substanzinduzierten Genexpressionsänderungen

also be obtained in vivo. The results, using the optimized system, show a deregulation at a level of 0.39 μM and a clear deregulation at a level of 6.25 μM methapyrilene. It is known from the literature, [...] simply based on the different pharmacokinetics in vitro and in vivo. Methapyrilene has a half-life of 2.8 h. The previous studies focused on 24 h as the earliest time point for sampling, therefore the substance …

Microsoft Word - Scheiner AP KONTIV Individualisierung.doc

Modell/ empirischer Wert (%) -0,4 -1,0 -1,4 -2,1 2,6 2,1 4,8 -4,3 42,9 36,5 18,4 13,8 -8,8 17,9 14,3 8,2 empirische Standardabweich. 0,25 0,23 0,25 0,39 0,40 0,42 0,43 0,49 0,40 0,44 0,42 0,47 0,43 0,42 0,42 [...] 44,8% 42,4% 43,0% 35,8% Versorgungsweg vorhanden? Signifikante Variablen 1976 15,1% 14,4% 14,4% 7,3% Signifikante Variablen 1982 14,8% 14,8% 14,6% 7,4% Signifikante Variablen 1989 14,7% 14,5% 14,8% 7,4% [...] Modell/ empirischer Wert (%) -0,8 -0,8 -3,6 -5,8 6,9 -9,5 -9,5 -10,4 0,0 21,6 31,4 30,2 -27,3 15,0 -7,5 -2,9 empirische Standardabweich. 0,17 0,17 0,18 0,39 0,42 0,39 0,42 0,50 0,47 0,46 0,40 0,44 0,49 …

(0,049) 0,021 (0,029) Hochschulabschluss 0,040 (0,051) -0,003 (0,030) Ostdeutschland -0,039 (0,070) -0,032 (0,039) Ländlich 0,026 (0,049) -0,034 (0,031) Temperatur -0,010 (0,025) -0,026 (0,016) # Regentage [...] Eigentum Stichprobe Deutschland (2018) Selbstgenutztes Eigentum 100% 44,0% Haushaltsgröße: 1 Person 8,8% 25,4% ... darunter weiblich 53,1% 57,6% 2 Personen 53,3% 42,4% 3+ Personen 37,9% 32,2% Einkommen > [...] Abwasser, da zusätzlich zum Wasserpreis auch der Abwasserpreis zu berücksichtigen ist, wenn die rea- 8 le Konsumentscheidung der Haushalte abgebildet werden soll (Schleich und Hillenbrand, 2009, S. 1758) …

6 17.8 0.02 -0.73 Capua 27.3 26.8 1.88 5.09 30.9 33.6 2.69 15.55 22.8 18.9 1.19 1.37 Caralis/Sa 37.6 22.0 0.30 -0.63 39.2 23.0 0.31 -0.62 35.1 20.0 0.26 -0.66 Carnuntum 33.2 14.7 -0.18 -0.64 33.8 14.0 [...] 21.5 0.51 -0.39 ProvNor 37.0 21.8 0.32 -0.61 36.5 22.4 0.40 -0.53 37.8 21.0 0.21 -0.69 ProvPan 36.2 23.6 0.53 -0.36 38.2 24.2 0.47 -0.44 32.4 21.6 0.59 -0.27 ProvRaet 38.7 27.5 0.74 0.04 40.8 28.3 0.68 [...] 38 -0.56 7 0.62 0.505 3 0.0194 0.0261 27.8 11.5 18.6 0.60 -0.26 25 0.505 0.064 male 1 0.0032 0.0812 34.5 39.8 13.0 -0.42 -0.36 3 0.771 0.853 2 0.0092 0.0360 36.8 38.0 20.1 0.18 -0.70 7 0.689 0.505 3 0.0201 …

= 1.7 · Be(0.8, 2.5) ( x 9.6 )0.8 ( 1− x 9.6 )2.5 · I[0,8](x) 7. Beta 2: f(x) = 1.7 · Be(2, 1.8) ( x 9.6 )2 ( 1− x 9.6 )1.8 · I[0,8](x) 8. Exponential: f(x) = 0.123 · (exp(x 3 )− 1) · I[0,8](x) 9. Peak: [...] 4,6,8) 250 √ 4.5 Emax 8 (0,1,2,3,4,5,6,7,8) 252 √ 4.5 Emax 9 (0,2,4,6,8) 250 √ 4.5 sigmoid Emax 10 (0,1,2,3,4,5,6,7,8) 252 √ 4.5 sigmoid Emax 11 (0,2,4,6,8) 250 √ 4.5 Beta 1 12 (0,1,2,3,4,5,6,7,8) 252 [...] 1 (0,2,4,6,8) 250 √ 4.5 Flat 2 (0,1,2,3,4,5,6,7,8) 252 √ 4.5 Flat 3 0,2,4,6,8) 250 √ 4.5 Linear 4 (0,1,2,3,4,5,6,7,8) 252 √ 4.5 Linear 5 (0,2,4,6,8) 250 √ 4.5 Quadratic 6 (0,1,2,3,4,5,6,7,8) 252 √ 4.5 …

Entwicklung eines in vitro Systems zur Untersuchung von substanzinduzierten Genexpressionsänderungen

also be obtained in vivo. The results, using the optimized system, show a deregulation at a level of 0.39 μM and a clear deregulation at a level of 6.25 μM methapyrilene. It is known from the literature, [...] simply based on the different pharmacokinetics in vitro and in vivo. Methapyrilene has a half-life of 2.8 h. The previous studies focused on 24 h as the earliest time point for sampling, therefore the substance …

885 885 885 885 800 800 ? s [mm] 16 8 8 8 8 8 12 Ap [mm²] 260 260 260 260 260 260 260 zp [mm] 825 825 825 825 825 825 825 ? p [mm] 25,8 25,8 25,8 25,8 25,8 25,8 25,8 » [-] 0,5 0,5 0,5 0,5 0,5 0,5 0,5 ´ [...] 455 ? s [mm] 16 8 8 8 8 8 12P As [mm²] 804,2 100,5 100,5 100,5 100,5 201 452 Es [N/mm²] 206.000 200.000 200.000 200.000 200.000 200.000 198.000 ? p [mm] 25,8 25,8 25,8 25,8 25,8 25,8 25,8 Ap [mm²] 260 260 [...] 5mm *2.000.000 200 675 8,9 35 1 41,8 41,8 1Ø26,5mm *2.000.000 160 675 8,9 35 1 41,8 41,8 1Ø26,5mm 113.000 250 675 8,9 35 1 41,8 41,8 1Ø26,5mm 417.000 200 675 8,9 35 1 41,8 41,8 Versuche von OERTLE ET AL …

68.1 60.8 6.5 26.9 98.2 126.8 163.5 71.8 5 3 3 5978040 Werne, Stadt 284.9 485.8 548.5 457.9 267.3 405.4 230.7 339.1 431.0 228.9 145.8 276.3 47.5 100.8 88.1 100.7 60.8 78.2 6.8 45.8 29.4 128.2 60.8 50.9 5 [...] 338.6 297.4 318.8 219.6 192.8 206.7 107.7 106.5 107.1 111.9 86.3 99.6 8 2 4 5570004 Ahlen, Stadt 485.6 432.8 460.2 300.8 292.2 296.6 184.8 140.7 163.5 80.7 55.9 68.7 104.2 84.8 94.8 8 2 4 5766008 Bad Salzuflen [...] 2,408 4,548 8,009 8,886 8,599 8,296 1,719 1,742 4,609 4,277 6,328 6,019 12,347 3,461 8,886 9 3 4 5158032 Velbert, Stadt 17,321 2,278 2,488 3,447 3,229 3,448 2,431 4,766 8,213 9,108 8,990 8,331 1,759 1 …

68.1 60.8 6.5 26.9 98.2 126.8 163.5 71.8 5 3 3 5978040 Werne, Stadt 284.9 485.8 548.5 457.9 267.3 405.4 230.7 339.1 431.0 228.9 145.8 276.3 47.5 100.8 88.1 100.7 60.8 78.2 6.8 45.8 29.4 128.2 60.8 50.9 5 [...] 338.6 297.4 318.8 219.6 192.8 206.7 107.7 106.5 107.1 111.9 86.3 99.6 8 2 4 5570004 Ahlen, Stadt 485.6 432.8 460.2 300.8 292.2 296.6 184.8 140.7 163.5 80.7 55.9 68.7 104.2 84.8 94.8 8 2 4 5766008 Bad Salzuflen [...] 2,408 4,548 8,009 8,886 8,599 8,296 1,719 1,742 4,609 4,277 6,328 6,019 12,347 3,461 8,886 9 3 4 5158032 Velbert, Stadt 17,321 2,278 2,488 3,447 3,229 3,448 2,431 4,766 8,213 9,108 8,990 8,331 1,759 1 …

very drastic options, such as a car ban (cf. Table 9). P1"?1)8*& G,18?-R& C#:*8 & 4& C#:*8 & 5& C#:*8 & 3& C#:*8 & S& C#:*8 & T& C#:*8 & U& C#:*8 & X& H:,#9$,9 ( ( ( F52..= ( F32.>; ( F52135( F52<>>( F>2 [...] "(&$#"(YE"%F &"+S"7(&:8X:%9(:X(EACD+&(9%$,#E:%9[('$#( $( 8"7+A8( "XX"&9(Y^>( _( /<;`( &X2( O+"D7( ><.5a( ?51[(b(9'"( :9'"%( $##"##8",9#( 7+XX"%(:,DQ( #D+-'9DQ( Y8:#9DQ(:8"-$ F #cA$%"7(:X($EE%:d+8$9"DQ(2<5[2( *'"( [...] $,7(5[($,7(..( YI:7"D(>[(&$#"#/(%"#E"&9+S"DQ2( 24 Weyer/Hoffmann P1"?1)8*& G,18?-R& C#:*8&4&C#:*8&5&C#:*8&3&C#:*8&S&C#:*8&T&C#:*8&U& H:,#9$,9 ( ( F<2?=?( F. 2?3. ( F; 255<( F?2>.; ( F; 2<00( F=2=.; ( H$%( …